2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178679
    3′-Azido-ddATP
    3′-Azido-ddATP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-Azido-ddATP
  • HY-W714077
    (2R,3S)-3-Methylmalic acid
    (2R,3S)-3-Methylmalic acid (compound 4b) is a synthon for 2-methyl-3-hydroxy-butyrolactones.
    (2R,3S)-3-Methylmalic acid
  • HY-W1008071
    3'-O-TBDMS-2'-O-Me-rG(iBu)
    3'-O-TBDMS-2'-O-Me-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-TBDMS-2'-O-Me-rG(iBu)
  • HY-172557
    2'(3')-Br-ANT-GTP tetrasodium
    2'(3')-Br-ANT-GTP tetrasodium is a derivative of GTP. 2'(3')-Br-ANT-GTP tetrasodium can be excited at 350 nm and emit at 380-550 nm.
    2'(3')-Br-ANT-GTP tetrasodium
  • HY-134033A
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium (2'-fluoro dATP) is a fluorinated derivative of ATP (HY-B2176). 2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium is a substrate and an inhibitor for E.coli DNA-dependent RNA polymerase, with a Ki of 200 µM.
    2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
  • HY-B0158S8
    Cytidine-d13
    		Chemical
    Cytidine-d13 (Cytosine β-D-riboside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>13</sub>
  • HY-104017R
    DMT-2'-O-MOE-rA(Bz) phosphoramidite (Standard)
    DMT-2'-O-MOE-rA(Bz) phosphoramidite (Standard) is the analytical standard of DMT-2'-O-MOE-rA(Bz) phosphoramidite (HY-104017). This product is intended for research and analytical applications. DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenine nucleoside analog. DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used in research on oligonucleotide synthesis.
    DMT-2'-O-MOE-rA(Bz) phosphoramidite (Standard)
  • HY-178621
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite
  • HY-137666
    2'-Deoxy-3',5'-GDP
    2'-Deoxy-3',5'-GDP (pdGp) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-Deoxy-3',5'-GDP
  • HY-112581S
    5-Methoxyuridine-d3
    5-Methoxyuridine-d3 is the deuterium labeled 5-Methoxyuridine (HY-112581). 5-Methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxyuridine-d<sub>3</sub>
  • HY-178664
    DMTr-2'-F-dU-3'-(L)-DPSE-phosphoramidite
    DMTr-2'-F-dU-3'-(L)-DPSE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-F-dU-3'-(L)-DPSE-phosphoramidite
  • HY-172731
    8-Oxo-dATP lithium
    8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription.
    8-Oxo-dATP lithium
  • HY-178534
    5-OH-CTP
    5-OH-CTP is a monomeric raw material that can be used for nucleic acid synthesis.
    5-OH-CTP
  • HY-154537
    3’-O-Methyl inosine
    3’-O-Methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Methyl inosine
  • HY-178540
    DMTr-dA(dmf)-3'-CE-phosphoramidite
    DMTr-dA(dmf)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-dA(dmf)-3'-CE-phosphoramidite
  • HY-W749893
    dGDP sodium
    dGDP (2'-Deoxyguanosine-5'-diphosphate) sodium is a monomeric raw material that can be used for nucleic acid synthesis.
    dGDP sodium
  • HY-178669
    5'-O-DMTr-3'-O-Me-rA(Bz)
    5'-O-DMTr-3'-O-Me-rA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-3'-O-Me-rA(Bz)
  • HY-171522
    LNA-AMP
    LNA-AMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-AMP
  • HY-178616
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac)
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac)
  • HY-W784574
    dCTPαS
    dCTPαS (2'-Deoxycytidine-5'-O-(1-thiotriphosphate)) is a monomeric raw material that can be used for nucleic acid synthesis.
    dCTPαS